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AC-260584

Chemical Structure : AC-260584

CAS No.: 560083-42-3

AC-260584 (AC260584)

Catalog No.: PC-42101Not For Human Use, Lab Use Only.

AC-260584 is a potent, selective, allosteric muscarinic M1 receptor agonist with pEC50 of 8.1, 7.6, 8.3 and 6.6 for WT M1, TM3 mutant W101A, L102A, and Y106A, repespectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AC-260584 is a potent, selective, allosteric muscarinic M1 receptor agonist with pEC50 of 8.1, 7.6, 8.3 and 6.6 for WT M1, TM3 mutant W101A, L102A, and Y106A, repespectively.
AC-260584  increases acetylcholine and dopamine release in rat medial prefrontal cortex and hippocampus.

Physicochemical Properties

M.Wt 348.4549
Formula C20H29FN2O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

2H-1,4-Benzoxazin-3(4H)-one, 4-[3-(4-butyl-1-piperidinyl)propyl]-7-fluoro-

References

1. Li Z, et al. Eur J Pharmacol. 2007 Oct 31;572(2-3):129-37.

2. Spalding TA, et al. Mol Pharmacol. 2006 Dec;70(6):1974-83.

3. Li Z, et al. Eur J Pharmacol. 2008 Oct 31;596(1-3):89-97.

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