AC-4067 | DDR1 inhibitor | Probechem Biochemicals

Chemical Structure : AC-4067

AC-4067 (AC4067)

Catalog No.: PC-26310Not For Human Use, Lab Use Only.

AC-4067 is a highly potent, selective inhibitor targeting discoidin domain receptor 1 (DDR1) with IC50 of 30.9 nM, 18-fold selectivity for DDR1 over DDR2.

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Biological Activity

AC-4067 is a highly potent, selective inhibitor targeting discoidin domain receptor 1 (DDR1) with IC50 of 30.9 nM, 18-fold selectivity for DDR1 over DDR2.
AC-4067 boosts WJ-MSC proliferation and scratch-wound closure.
AC-4067 treatment reduces SA-βgal activity and replicative senescence.
AC-4067 suppresses DNA damage by reducing γH2AX levels in late-passage mesenchymal stem cells (MSCs).

Physicochemical Properties

M.Wt	517.47
Formula	C27H18F3N5O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1,3-dioxo-5-(pyrimidin-5-ylamino)isoindolin-2-yl)-4-methyl-N-(3-(trifluoromethyl)phenyl)benzamide

References

1. Nada H, et al. Biomed Pharmacother. 2026 Mar 6;197:119182.

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AC-4067 (AC4067)

Biological Activity

Physicochemical Properties

References

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