AC3573 | HER3 inhibitor | Probechem Biochemicals

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Chemical Structure : AC3573

AC3573 (AC-3573)

Catalog No.: PC-72379Not For Human Use, Lab Use Only.

AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM.

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Biological Activity

AC3573 (AC-3573) is a potent, specific small molecule inhibitor of HER3 with IC50 of 4 uM.
AC3573 abrogates HER2–HER3 signalling in cells and is more specific for HER3, inhibits NRG (heregulin)-induced HER3 phosphorylation with IC50 of 10 uM, abrogates the formation of the active HER2-HER3 heterodimer, inhibits oncogenic downstream signalling in SK-BR-3 breast cancer cells.

Physicochemical Properties

M.Wt	365.411
Formula	C18H15N5O2S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-[[6-(1H-Indol-3-yl)-4-pyrimidinyl]amino]benzenesulfonamide

References

1. Audrey Colomba, et al. Biochem J. 2020 Sep 18;477(17):3329-3347.

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AC3573 (AC-3573)

Biological Activity

Physicochemical Properties

References

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