ACC2 inhibitor 2e

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Chemical Structure : ACC2 inhibitor 2e

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Catalog No.: PC-73298Not For Human Use, Lab Use Only.

ACC2 inhibitor 2e is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 1.9 nM and 1950 nM for ACC2 and ACC1, respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ACC2 inhibitor 2e is a highly potent and selective acetyl-CoA carboxylase 2 (ACC2) inhibitor with IC50 of 1.9 nM and 1950 nM for ACC2 and ACC1, respectively.
ACC2 inhibitor 2e exhibited good PK profile and in vivo antidiabetic efficacy in C57BL/6 mice.

Physicochemical Properties

M.Wt	417.908
Formula	C20H20ClN3O3S
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	(S,E)-N-(4-(6-((7-chloro-2-ethoxybenzo[d]thiazol-6-yl)oxy)pyridin-3-yl)but-3-en-2-yl)acetamide

References

1. Nishiura Y, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2498-2503.

2. Takagi H, et al. J Pharmacol Exp Ther. 2020 Mar;372(3):256-263.

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