ACD856 | pan-Trk PAM | Probechem Biochemicals

Chemical Structure : ACD856

ACD856 (ACD-856)

Catalog No.: PC-23114Not For Human Use, Lab Use Only.

ACD856 is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 382 nM, 295 nM and 33 nM for TrkA, TrkB and TrkC respectively.

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Biological Activity

ACD856 is a potent, pan-Trk positive allosteric modulator (PAM) with EC50 of 382 nM, 295 nM and 33 nM for TrkA, TrkB and TrkC respectively.
ACD856 shows high efficacy on activation of neurotrophin (TrkA, TrkB or TrkC, Emax, 185%, 176%, 328%), with little efficacy on IGF1R and FGFR1.
ACD856 could significantly increase the Vmax(app) of TrkA.
ACD856 (0.1, 0.3 or 1 mg/kg) reverses memory-impairment in the passive avoidance task in mice.
ACD856 improves the acquisition, consolidation, and retrieval of memories.

Physicochemical Properties

M.Wt
Formula
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

References

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ACD856 (ACD-856)

Biological Activity

Physicochemical Properties

References

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