Chemical Structure : ACHM-025
CAS No.:
2377718-85-7
ACHM-025
(ACHM025)
Catalog No.: PC-23372Not For Human Use, Lab Use Only.
ACHM-025 is a third generation AKR1C3-activated prodrug, selectively activates by AKR1C3 in the presence of NADPH to form the nitrogen mustard DNA alkylating agent.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ACHM-025 is a third generation AKR1C3-activated prodrug, selectively activates by AKR1C3 in the presence of NADPH to form the nitrogen mustard DNA alkylating agent.
ACHM-025 showsa strong and significant correlation with basal AKR1C3 protein expression, shows selectivity for activation by the AKR1C3 isoform, compared to AKR1C1, AKR1C2 and AKR1C4 in HCT116 cells.
ACHM-025 has potent in vivo efficacy against T-ALL patient-derived xenografts (PDXs) and eradicated the disease in 7 PDXs.
ACHM-025 was significantly more effective than cyclophosphamide both as a single agent and when used in combination with cytarabine/6-mercaptopurine.
ACHM-025 ex vivo cytotoxicity shows a significant inverse correlation with AKR1C3 mRNA expression.
Physicochemical Properties
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M.Wt
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544.61
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Formula
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C17H28N4O10S3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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((2-((4-methylpiperazin-1-yl)sulfonyl)-4-nitrophenyl)azanediyl)bis(ethane-2,1-diyl) dimethanesulfonate
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References
1. Toscan CE, et al. Blood Cancer J. 2024 Nov 6;14(1):192.
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