ACLY inhibitor VCB1

Chemical Structure : ACLY inhibitor VCB1

Catalog No.: PC-28484Not For Human Use, Lab Use Only.

ACLY inhibitor VCB1 is a potent, small molecule ATP citrate lyase (ACLY) inhibitor with IC50 of 0.9 uM, strongly suppresses lymphoma cell growth.

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Biological Activity

ACLY inhibitor VCB1 is a potent, small molecule ATP citrate lyase (ACLY) inhibitor with IC50 of 0.9 uM, strongly suppresses lymphoma cell growth.
VCB1 shows an IC50 of 0.299 μM and retains potency in lorlatinib-resistant SUPM2-LR1000 cells (1.62 μM).
VCB1 inhibits BTK inhibitor sensitive and resistant mantle cell lymphoma cell growth (IC50, 0.28 and 0.278 μM).
VCB1 activates the integrated stress response (ISR), inducing ATF4, PPP1R15A, DDIT3, DDIT4 and SESN2, while disrupting purine and pyrimidine metabolism and reducing nucleotide biosynthetic genes, including CAD, DHODH, UCK2, and ATIC.
VCB1 also alters immune-regulatory programs involving PDCD1, TIGIT, CD247, CD226, NFATC2, and inflammatory cytokines.
VCB1 induces cell cycle arrest and apoptosis across TKI-sensitive and resistant lymphoma models.

Physicochemical Properties

M.Wt	467.31
Formula	C22H16Cl2N6O2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,2'-((1E,1'E)-(phthalazine-1,4-diylbis(hydrazin-2-yl-1-ylidene))bis(methaneylylidene))bis(4-chlorophenol)

References

1. Pattabiraman N, et al. bioRxiv [Preprint]. 2026 Oct 4:2026.09.29.755331.