ACP1-01

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Chemical Structure : ACP1-01

Catalog No.: PC-25350Not For Human Use, Lab Use Only.

ACP1-01 is a small molecule activator of bacterial ClpP with EC50 of 3.4 μM and 2.6 μM for NmClpP and EcClpP respectively, noncovalently binds to ClpP C sites and activates the protease, shows antibacterial activity by virtue of the ability to dysregulate the cylindrical protease.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

Physicochemical Properties

M.Wt	500.47
Formula	C19H18F6N2O3S2
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-methyl-N-(2-((2-(trifluoromethyl)phenyl)thio)ethyl)-2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)propanamide

References

1. Barghash MM, et al. Structure. 2025 Aug 5:S0969-2126(25)00261-8.

2. Binepal G, et al. ACS Infect Dis. 2020 Dec 11;6(12):3224-3236.

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ACP1-01

Biological Activity

Physicochemical Properties

References

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