Chemical Structure : ACX-801
CAS No.:
ACX-801
(ACX801)
Catalog No.: PC-25701Not For Human Use, Lab Use Only.
ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ACX-801 is a potent specific antibiotic for Gram-positive priority pathogens targeting the PolC DNA polymerase (IC50=5.8 uM, E. faecium PolC), demonstrates potent activity against drug-resistant priority pathogens (VRE, MRSA and PRSP), with no activity against Gram-negative bacterium E. coli.
ACX-801 shows selective inhibition of E. faecium PolC, with no significant inhibition observed against DnaE-type DNA polymerases: Pol IIIα from E. coli33,34 and DnaE of E. faecium.
F1276 position of PolC shows susceptibility to ACX-801 both in vivo and in vitro.
Physicochemical Properties
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M.Wt
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383.29
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Formula
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C15H12F3N5O4
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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5-(((2,2-difluorobenzo[d][1,3]dioxol-5-yl)methyl)amino)-3-fluoro-1-(2-hydroxyethyl)-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
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References
1. Urem M, et al. Nat Commun. 2025 Nov 6;16(1):9784.
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