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Chemical Structure : ACY-775
CAS No.: 1375466-18-4
Catalog No.: PC-70106Not For Human Use, Lab Use Only.
ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $118 | In stock | |
| 10 mg | $188 | In stock | |
| 25 mg | $348 | In stock | |
| 50 mg | $548 | In stock | |
| 100 mg | Get quote |
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ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability.
ACY-775 displays 60-1500 fold selectivity over class I HDACs, no activity against all other class II HDAC isoforms (IC50>1 uM).
ACY-775 induces dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors.
ACY-775 increases the innervation of the neuromuscular junctions in the gastrocnemius muscle and improves the motor and sensory nerve conduction in the mutant HSPB1-induced CMT2 mouse model.
| M.Wt | 330.36 | |
| Formula | C17H19FN4O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
2-((1-(3-fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide |
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1. Jochems J, et al. Neuropsychopharmacology. 2014 Jan;39(2):389-400.
2. Benoy V, et al. Neurotherapeutics. 2017 Apr;14(2):417-428.
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