Catalog No.: PC-35363Not For Human Use, Lab Use Only.
ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).
ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).
ACY-957 elicits dependent induction of γ-globin mRNA (HBG) and HbF protein in a variety of primary erythroid progenitor cell culture system.
ACY-957 increases GATA2 expression, elevates histone acetylation at well-known GATA2 autoregulatory regions.
