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Chemical Structure : ACY-957
CAS No.: 1609389-52-7
Catalog No.: PC-35363Not For Human Use, Lab Use Only.
ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $258 | In stock | |
| 10 mg | $398 | In stock | |
| 25 mg | $598 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ACY-957 (ACY957) is a potent, selective inhibitor of HDAC1 and HDAC2 with IC50 of 7 and 18 nM, shows limited activity against HDAC3 (IC50=1,300 nM) and no activity against HDAC4/5/6/7/8/9 (IC50>20 nM).
ACY-957 elicits dependent induction of γ-globin mRNA (HBG) and HbF protein in a variety of primary erythroid progenitor cell culture system.
ACY-957 increases GATA2 expression, elevates histone acetylation at well-known GATA2 autoregulatory regions.
| M.Wt | 429.542 | |
| Formula | C24H23N5OS | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
N-[2-Amino-5-(2-thienyl)phenyl]-2-(1-piperazinyl)-6-quinolinecarboxamide |
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1. Shearstone JR, et al. PLoS One. 2016 Apr 13;11(4):e0153767.
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