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AD-35 hydrochloride

Chemical Structure : AD-35 hydrochloride

CAS No.: 1531586-62-5

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AD-35 hydrochloride (AD35 hydrochloride;AD 35 hydrochloride)

Catalog No.: PC-60067Not For Human Use, Lab Use Only.

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

A donepezil analog that can moderately inhibit acetylcholinesterase and metal-induced Aβ aggregation in vitro and shows disassembly of Aβ aggregates; markedly attenuates Aβ25-35 injection-induced astrocyte activation, pro-inflammatory cytokines TNF-α and IL-1β release, and memory deficits in vivo; orally active.

Physicochemical Properties

M.Wt 441.956
Formula C24H28ClN3O3
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6'-(2-(1-(pyridin-2-ylmethyl)piperidin-4-yl)ethyl)spiro[cyclopropane-1,5'-[1,3]dioxolo[4,5-f]isoindol]-7'(6'H)-one hydrochloride

References

1. Li L, et al. J Alzheimers Dis. 2017;56(4):1403-1417.

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