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AD 2900

Chemical Structure : AD 2900

CAS No.: 18360-29-7

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AD 2900 (AD2900;AD-2900)

Catalog No.: PC-60340Not For Human Use, Lab Use Only.

AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
    AD 2900 shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs.
    AD 2900 accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes.
    AD 2900 shows significant effects on the localization of T-cell subpopulations in mic.
     

    Physicochemical Properties

    M.Wt 345.568
    Formula C20H43NO3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(hexadecylamino)-2-(hydroxymethyl)propane-1,3-diol

    References

    1. Song J, et al. Oncotarget. 2017 Jun 27;8(32):53563-53580.

    2. Dagan A, et al. Biochim Biophys Acta. 2003 Sep 22;1633(3):161-9.

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