Catalog No.: PC-60340Not For Human Use, Lab Use Only.
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
AD 2900 (AD2900, AD-2900) is a novel potent, broad S1P receptor antagonist with IC50 of 3.8, 3.2, 6.2, 5.9 and 0.405 uM for S1P1, 2, 3, 4 and 5 respectively.
AD 2900 shows no significant agonism effects (EC50>50 uM); suppresses PBMC proliferation, regulates the expression of S1P1 and CCR7 on PBMCs.
AD 2900 accumulates T cells in the blood and spleen and in turn reduces T-cell number in the lymph nodes.
AD 2900 shows significant effects on the localization of T-cell subpopulations in mice.
