ADH-1 (Exherin, ADH1, N-Ac-CHAVC-NH2) is a cyclic pentapeptide N-cadherin antagonist, disrupts N-cadherin adhesion complexes and inhibits N-cadherin mediated cell adhesion. ADH-1 inhibit the neurite outgrowth response stimulated by N-cadherin. ADH-1 prevents collagen I-induced cell scattering and cell migration in pancreatic cancer cells. ADH-1 induces apoptosis in a dose-dependent and N-cadherin-dependent manner. ADH-1 50 mg/kg (i.p. 1× per day, 5× per week for 4 weeks) prevents tumor growth in a mouse model for pancreatic cancer.
