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Chemical Structure : ADL06
Catalog No.: PC-23203Not For Human Use, Lab Use Only.
ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin.
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ADL06 is a selective small-molecule Gi protein-biased agonist/ ligand of delta opioid receptor (DOR, δOR) with pEC50 of 6.5 in Gi protein signal pathway, with ignificantly diminished effect on β-arrestin.
ADL06 exhibited almost no activation ability for μOR and κOR.
ADL06 does not exhibit the gastrointestinal (GI) inhibition commonly observed with ADL5859 and SNC80.
ADL06 (i.p., 0.06 mmol/kg, 29 mg/kg) effectively alleviated visceral pain in chronic constriction injury (CCI)-induced neuropathic pain models.
| M.Wt | 448.61 | |
| Formula | C28H36N2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Cheng L, et al. Nat Commun. 2024 Sep 27;15(1):8284.
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