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Chemical Structure : ADL5859
CAS No.: 850173-95-4
Catalog No.: PC-43352Not For Human Use, Lab Use Only.
ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $98 | In stock | |
| 10 mg | $158 | In stock | |
| 25 mg | $278 | In stock | |
| 50 mg | Get quote | ||
| 100 mg | Get quote |
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ADL5859 is a potent, selective, orally bioavailable full agonist of δ opioid receptor (DOR) with Ki of 0.84 nM and EC50 of 20 nM.
ADL5859 exhibits >1,000-fold selectivity for δ over µ and κ opioid receptors in both receptor binding and in vitro bioassays.
ADL5859 demonstrates analgesic and antidepressive effects in the rat and represent potential drug for chronic pain treatment, significantly reduces inflammatory and neuropathic pain, does not induce either hyperlocomotion or receptor internalization in vivo.
| M.Wt | 428.9517 | |
| Formula | C24H29ClN2O3 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Benzamide, N,N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2,4'-piperidin]-4-yl)-, hydrochloride (1:1) |
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1. Le Bourdonnec B, et al. J Med Chem. 2008 Oct 9;51(19):5893-6.
2. Nozaki C, et al. J Pharmacol Exp Ther. 2012 Sep;342(3):799-807.
3. Huang P, et al. Eur J Pharmacol. 2016 Jun 15;781:53-9.
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