Chemical Structure : ADRIANA
CAS No.:
719277-27-7
ADRIANA
(c545, Adrenergic inducer of analgesia)
Catalog No.: PC-25232Not For Human Use, Lab Use Only.
ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
ADRIANA (c545) is a potent, orally active α2B adrenoceptor subtype-specific antagonist with binding Ki of 987 nM, >50-fold selective over α2A adrenoceptor.
ADRIANA shows no binding affinity for αl-adrenergic receptors in radioligand binding assay.
ADRIANA specifically promotes noradrenaline release in the murine spinal dorsal horn and produces analgesic effects by stimulating the α2A-dependent pain inhibitory pathway.
ADRIANA shows potent analgesic effects in several nociceptive pain models of mice and nonhuman primates without cardiovascular effects.
Physicochemical Properties
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M.Wt
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237.29
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Formula
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C12H12FNOS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(Z)-1-(3-ethyl-5-fluorobenzo[d]thiazol-2(3H)-ylidene)propan-2-one
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References
1. Toyomoto M, et al. Proc Natl Acad Sci U S A. 2025 Aug 12;122(32):e2500006122.
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