ADS1017 trihydrochloride

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Chemical Structure : ADS1017 trihydrochloride

Catalog No.: PC-23593Not For Human Use, Lab Use Only.

ADS1017 trihydrochloride is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ADS1017 trihydrochloride is a potent, selective histamine H3 receptor antagonist with pKi of 7.9/6.8 for rH3R/hH3R in radioligand binding assays respectively, 20-fold selective over H4R.
ADS1017 demonstrates marked H3 receptor antagonist activity in the guinea pig jejunum functional assay (gpH3R pA2 = 8.21) and weak but competitive antagonism toward H1R with pA2 = 6.70.
ADS1017 shows a broad spectrum of analgesic activity in both nociceptive and neuropathic pain models.

Physicochemical Properties

M.Wt	589.09
Formula	C29H48Cl3N5O
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-benzyl-1-(4-(4-(7-phenoxyheptyl)piperazin-1-yl)butyl)guanidine trihydrochloride

References

1. Karcz T, et al. ACS Chem Neurosci. 2024 Dec 9. doi: 10.1021/acschemneuro.4c00480.

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