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Chemical Structure : ADU-S100
CAS No.: 1638241-89-0
Catalog No.: PC-43283Not For Human Use, Lab Use Only.
ADU-S100 (MIW815, ML RR-S2 CDA) is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 1 mg | $288 | In stock | |
| 2 mg | $458 | In stock | |
| 5 mg | $758 | In stock | |
| 10 mg | Get quote |
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ADU-S100 (MIW815, ML RR-S2 CDA) is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.
ADU-S100 also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.
ADU-S100 demonstrates profound anti-tumor efficacy in established B16 melanoma.
| M.Wt | 690.5431 | |
| Formula | C20H24N10O10P2S2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide |
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1. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30.
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