ADU-S100 ammonium salt
(2’3’-c-di-AM(PS)2 (Rp,Rp) (ammonium salt), ML RR-S2 CDA, MIW815)
Catalog No.: PC-43284Not For Human Use, Lab Use Only.
ML RR-S2 CDA ammonium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
ADU-S100 (ML RR-S2 CDA ammonium salt, MIW815) is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.
ML RR-S2 CDA ammonium salt shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.
ML RR-S2 CDA ammonium salt also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.
ML RR-S2 CDA ammonium salt demonstrates profound anti-tumor efficacy in established B16 melanoma.
Physicochemical Properties
M.Wt
724.604124
Formula
C20H30N12O10P2S2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
DMSO: 15 mg/mL; H2O: 12.5 mg/mL
Chemical Name/SMILES
Adenosine, [P(R)]-5'-O-[(R)-hydroxymercaptophosphinyl]-P-thioadenylyl-(2'→5')-, cyclic nucleotide, ammonium salt (1:2)
References
1. Corrales L, et al. Cell Rep. 2015 May 19;11(7):1018-30.
