ADU-S100 (MIW815, ML RR-S2 CDA) | STING agonist

Chemical Structure : ADU-S100 disodium salt

CAS No.: 1638750-95-4

ADU-S100 disodium salt (MIW815, 2’3’-c-di-AM(PS)2 (Rp,Rp), ML RR-S2 CDA)

Catalog No.: PC-62639Not For Human Use, Lab Use Only.

ADU-S100 (MIW815, ML RR-S2 CDA) disodium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.

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Biological Activity

ADU-S100 (MIW815, ML RR-S2 CDA) disodium salt is a synthetic cyclic dinucleotide derivative that functions as a highly potent agonist of STING, enhances binding affinity to STING and activates all known human STING alleles.

ADU-S100 shows enhanced type I IFN production over CDA in THP-1 human monocytes, induces the highest expression of IFN-β and the pro-inflammatory cytokines TNF-α, IL-6, and MCP-1 on a molar equivalent basis, as compared to endogenous ML cGAMP and the TLR3 agonist poly I:C.

ADU-S100 also induces aggregation of STING and induces phosphorylation of TBK1 and IRF3 in mouse BMM, induces significantly higher levels of IFN-α when compared to ML cGAMP.

ADU-S100 demonstrates profound anti-tumor efficacy in established B16 melanoma.

Physicochemical Properties

M.Wt	734.5
Formula	C20 H24 N10 O10 P2 S2 . 2 Na
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2R,5R,7R,8R,10R,12aR,14R,15R,15aS,16R)-7,14-Bis(6-amino-9H-purin-9-yl)-15,16-dihydroxy-2,10-dimercaptooctahydro-12H-5,8-methanofuro[3,2-l][1,3,6,9,11]pentaoxa[2,10]diphosphacyclotetradecine 2,10-dioxide disodium salt

References

1. Cancer Discov. 2018 Jan 25. doi: 10.1158/2159-8290.CD-ND2018-002.

ADU-S100 disodium salt (MIW815, 2’3’-c-di-AM(PS)2 (Rp,Rp), ML RR-S2 CDA)

Biological Activity

Physicochemical Properties

References

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