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AE-848

Chemical Structure : AE-848

CAS No.: 384843-95-2

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AE-848 (AE848)

Catalog No.: PC-21362Not For Human Use, Lab Use Only.

AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

AE-848 is a small molecule modulator of NF-κB and PI3K/AKT/mTOR signaling pathways, shows potent in vitro and in vivo anti-myeloma activity.
AE-848 (5 µM, 24 and 48 h) significantly induces apoptosis of U266 and RPMI8226 cells, markedly induces loss of MMP.
AE-848 induces cleavage of caspase-8, caspase-3, and PARP, induces apoptosis in a caspase-dependent manner and inhibits the NF-κB and PI3K/Akt/mTOR signaling pathways.
AE-848 (12.5 mg/kg, i.p.) significantly inhibits tumor growth and prolongs overall survival of MM cell-bearing mice.

Physicochemical Properties

M.Wt 517.39
Formula C24H21BrN8O
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
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Solubility

10 mM in DMSO
Chemical Name/SMILES

4-bromo-2,6-bis((E)-(2-(1-methyl-1H-benzo[d]imidazol-2-yl)hydrazineylidene)methyl)phenol

References

1. Xu Y, et al. Onco Targets Ther. 2020 Dec 22;13:13063-13075.

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