Chemical Structure : AF710B
CAS No.:
3111245-04-3
AF710B
((S)-AF710)
Catalog No.: PC-28113Not For Human Use, Lab Use Only.
AF710B ((S)-AF710) is a highly potent and selective allosteric M1 muscarinic and σ1 receptor (M1 mAChR/σ1R) agonist.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AF710B ((S)-AF710) is a highly potent and selective allosteric M1 muscarinic and σ1 receptor (M1 mAChR/σ1R) agonist.
AF710B significantly potentiates the binding and efficacy of carbachol on M1 receptors and their downstream effects (p-ERK1/2, p-CREB).
AF710B binds with high affinity to M1 mAChR showing an allosteric agonistic profile.
AF710B binds with high affinity to σ1R and does not bind to σ2R (IC50> 10 μM).
AF710B potentiates the effects induced by carbachol and improves cognition in a passive avoidance test in trihexyphenidyl-treated rats.
AF710B shows exceptional efficacy in restoring cognitive decline associated with AD and with lessening BACE1, GSK3β activity, p25CDK5, neuroinflammation, soluble and insoluble Aβ40, Aβ42, accumulation of amyloid plaques and neurofibrillary tangles.
Physicochemical Properties
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M.Wt
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357.52
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Formula
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C20H27N3OS
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(S)-1-(2,8-dimethyl-1-thia-3,8-diazaspiro[4.5]decan-3-yl)-3-(1H-indol-3-yl)propan-1-one
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References
1. Fisher A, et al. Neurodegener Dis. 2016;16(1-2):95-110.
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