AFP464 | HIF-1α inhibitor, AhR ligand

Chemical Structure : AFP464

AFP464 (NSC710464)

Catalog No.: PC-26120Not For Human Use, Lab Use Only.

AFP464 (NSC710464) is a prodrug form of Aminoflavone and a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion (IC50=0.25 uM).

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Biological Activity

AFP464 (NSC710464) is a prodrug form of Aminoflavone and a small molecule aryl hydrocarbon receptor (AhR) ligand, inhibits HIF-1alpha expression in an AhR-independent fashion (IC50=0.25 uM).

Physicochemical Properties

M.Wt	448.45
Formula	C22H23F3N4O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	Hexanamide, 2,6-diamino-N-[4-(5-amino-6,8-difluoro-7-methyl-4-oxo-4H-1-benzopyran-2-yl)-2-fluorophenyl]-, (2S)-

References

1. Terzuoli E, et al. Cancer Res. 2010 Sep 1;70(17):6837-48.

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AFP464 (NSC710464)

Biological Activity

Physicochemical Properties

References

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