AG-1295 (Tyrphostin AG1295) is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
AG-1295 inhibits PDGF-stimulated DNA synthesis with IC50 of 2.5 uM without affecting activity of EGFR.
AG-1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.
Physicochemical Properties
M.Wt
234.3
Formula
C16H14N2
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6,7-dimethyl-2-phenyl-quinoxaline
References
1. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.
2. Banai S, et al. Circulation. 1998 May 19;97(19):1960-9.
