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Chemical Structure : AG-1295
CAS No.: 71897-07-9
Catalog No.: PC-61280Not For Human Use, Lab Use Only.
A quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 10 mg | $88 | In stock | |
| 25 mg | $148 | In stock | |
| 50 mg | $238 | In stock | |
| 100 mg | Get quote |
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AG-1295 (Tyrphostin AG1295) is a quinoxaline-type tyrphostin that acts as a potent and selective inhibitor of PDGFR kinase in vitro and in Swiss 3T3 cells with IC50 of 0.3-1 uM.
AG-1295 inhibits PDGF-stimulated DNA synthesis with IC50 of 2.5 uM without affecting activity of EGFR.
AG-1295 selectively attenuates smooth muscle cell growth in vitro and reduces neointimal formation after balloon angioplasty in swine.
| M.Wt | 234.3 | |
| Formula | C16H14N2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
6,7-dimethyl-2-phenyl-quinoxaline |
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1. Kovalenko M, et al. Cancer Res. 1994 Dec 1;54(23):6106-14.
2. Banai S, et al. Circulation. 1998 May 19;97(19):1960-9.
3. Iwamoto H, et al. J Lab Clin Med. 2000 May;135(5):406-12.
4. Karck M, et al. Transplantation. 2002 Nov 15;74(9):1335-41.
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