AG-205 | PGRMC1 inhibitor | Probechem Biochemicals

Chemical Structure : AG-205

AG-205 (AG205;AG 205)

Catalog No.: PC-70186Not For Human Use, Lab Use Only.

AG-205 is a small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.

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Biological Activity

AG-205 is a small molecule inhibitor of progesterone receptor membrane component 1 (PGRMC1) that alters the spectroscopic properties of the PGRMC1-heme complex.
AG-205 decreases GLP-1-induced insulin secretion in β cells.
AG-205 inhibits cancer cell viability and cancer cell progression, acting preferentially on PGRMC1-expressing cells.

Physicochemical Properties

M.Wt	454.98
Formula	C22H23ClN6OS
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-[[1-(4-Chlorophenyl)-1H-tetrazol-5-yl]thio]-1-(1,2,3,4,4a,9b-hexahydro-2,8-dimethyl-5H-pyrido[4,3-b]indol-5-yl)ethanone

References

1. Privett BR, et al. Biochemistry. 2017 Jul 25;56(29):3840-3849.

2. Zhang M, et al. Mol Cell Proteomics. 2014 Nov;13(11):3049-62.

3. Mir SU, et al. Int J Cancer. 2012 Jul 15;131(2):E1-9.

4. Terzaghi L, et al. Cell Cycle. 2016 Aug 2;15(15):2019-32.

AG-205 (AG205;AG 205)

Biological Activity

Physicochemical Properties

References

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