Catalog No.: PC-26483Not For Human Use, Lab Use Only.
AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively.
AG-670 (PU02) is a small molecule inhibitor of nicotinamide N-methyltransferase (NNMT) with EC50 of 2.7 uM, also is a negative allosteric modulator (NAM) of 5-HT3 receptor with IC50 of 0.36 and 0.73 uM in HEK293 cells transfected with human 5-HT3A and 5-HT3AB receptors respectively. AG-670 inhibits SCC-4 cell viability with IC50 of 41.8 uM. AG-670 (10 uM) inhibits cellular oxygen consumption or in situ mitochondrial oxygen consumption in MCF 7 cells.
Physicochemical Properties
M.Wt
292.36
Formula
C16H12N4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
6-[(1-Naphthalenylmethyl)thio]-9H-purine
References
1. Maloney B, et al. Pharmaceuticals (Basel). 2026 Mar 22;19(3):516.
2. Sarah M Trattnig, et al. J Biol Chem. 2012 Jul 20;287(30):25241-54.
