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AG-7404

Chemical Structure : AG-7404

CAS No.: 343565-99-1

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AG-7404 (AG7404, V-7404)

Catalog No.: PC-20017Not For Human Use, Lab Use Only.

AG-7404 (V-7404) is a potent, irreversible inhibitor of picornaviral 3C protease, exhibits EC50 values of 80-674 nM against a large panel of programmatically important poliovirus strains.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AG-7404 (V-7404) is a potent, irreversible inhibitor of picornaviral 3C protease, exhibits EC50 values of 80-674 nM against a large panel of programmatically important poliovirus strains.
    AG-7404 was fully active against all Pocapavir (V-073)-resistant variants, with EC50 values ranging from 0.218 to 0.819 μM, compared to values of 0.202-0.407 μM for the V-073-susceptible parental strains.
    AG-7404 demonstrated synergy effect with either V-073 or BTA798.

    Physicochemical Properties

    M.Wt 523.55
    Formula C26H29N5O7
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl (S,E)-4-((S)-2-(3-(5-methylisoxazole-3-carboxamido)-2-oxopyridin-1(2H)-yl)pent-4-ynamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

    References

    1. Eric Rhoden, et al. Antiviral Res. 2013 May;98(2):186-91.

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