AG14361 is a potent, specific and competitive inhibitor of PARP-1 with Ki of 5.8 nM。
AG14361 shows potent amplification of the cytotoxic effects of temozolomide (TM) and topotecan (TP) against A549 cells, inhibits LoVo Cell Line with GI50 of 11.2 uM alone。
AG14361 increases the delay of LoVo xenograft growth induced by irinotecan, x-irradiation, or temozolomide by two- to threefold with nontoxicity, causes complete regression of SW620 xenograft tumors combined with temozolomide.
