AGH-192 | 5-HT7 agonist | Probechem Biochemicals

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Chemical Structure : AGH-192

AGH-192 (AGH192)

Catalog No.: PC-73304Not For Human Use, Lab Use Only.

AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AGH-192 is a potent, selective, orally bioavailable 5-HT7 receptor agonist with Ki of 4 nM.
AGH-192 displays excellent water solubility, high selectivity over related CNS targets, high metabolic stability, oral bioavailability and low cytotoxicity.
AGH-192 could crosses blood-brain barrier to a high extent.
AGH-192 alleviates the symptoms of neuropathic pain in a mouse model.

Physicochemical Properties

M.Wt	355.155
Formula	C13H11FIN3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	3-(1-ethyl-1H-imidazol-5-yl)-5-iodo-4-fluoro-1H-indole

References

1. Adam S Hogendorf, et al. Eur J Med Chem. 2019 May 15;170:261-275.

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AGH-192 (AGH192)

Biological Activity

Physicochemical Properties

References

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