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AGI-6780

Chemical Structure : AGI-6780

CAS No.: 1432660-47-3

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AGI-6780 (AGI 6780;AGI6780)

Catalog No.: PC-44670Not For Human Use, Lab Use Only.

AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM.

Packing Price Stock Quantity
5 mg (Free Sample) $28 In stock
25 mg $188 In stock
50 mg $288 In stock
100 mg $448 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AGI-6780 is a potent and selective mutant IDH2 R140Q inhibitor with IC50 of 23 nM.
AGI-6780 shows excellent selectivity against other dehydrogenases.
AGI-6780 induces differentiation of TF-1 erythroleukemia and primary human acute myelogenous leukemia cells in vitro.

Physicochemical Properties

M.Wt 481.5111
Formula C21H18F3N3O3S2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

DMSO: ≥ 29 mg/mL
Chemical Name/SMILES

Benzenesulfonamide, N-cyclopropyl-4-(3-thienyl)-3-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-

References

1. Wang F, et al. Science. 2013 May 3;340(6132):622-6.

2. Kernytsky A, et al. Blood. 2015 Jan 8;125(2):296-303.

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