Welcome to ProbeChem!Global Supplier of Chemical Probes, Inhibitors & Agonists.
Chemical Structure : AGN 225660
Catalog No.: PC-20529Not For Human Use, Lab Use Only.
AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively.
Bulk size, bulk discount!
E-mail: sales@probechem.com
Tech Support: tech@probechem.com
AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively.
AGN 225660 dose-dependently inhibited LPS-induced RANTES and TNFα induced release of IL-8, MCP-1, and RANTES from human primary macrophages.
AGN 225660 increased LPS-induced MCP-1 secretion (up to 2-fold) from human monocyte-derived dendritic cells.
AGN 225660 exhibited good ocular bioavailability and was active in reducing ocular inflammation associated with phacoemulsification surgery, LPS, and arachidonic acid induced uveitis.
| M.Wt | 378.90 | |
| Formula | C20H27ClN2O3 | |
| Appearance | Solid | |
| Storage |
|
|
| Solubility |
10 mM in DMSO |
|
1. David F Woodward, et al. ACS Pharmacol Transl Sci. 2020 Oct 26;3(6):1199-1210.
Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright
