Chemical Structure : AGN 225660
CAS No.:
1354060-46-0
AGN 225660
(AGN225660)
Catalog No.: PC-20529Not For Human Use, Lab Use Only.
AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AGN 225660 is a second-generation prostanoid receptor antagonist acting at multiple receptor subtypes with IC50 of 220/70/2900/7100/70/180/1100/5 nM for DP1/EP1/EP2/EP3/EP4/FP/IP/TP receptors, respectively.
AGN 225660 dose-dependently inhibited LPS-induced RANTES and TNFα induced release of IL-8, MCP-1, and RANTES from human primary macrophages.
AGN 225660 increased LPS-induced MCP-1 secretion (up to 2-fold) from human monocyte-derived dendritic cells.
AGN 225660 exhibited good ocular bioavailability and was active in reducing ocular inflammation associated with phacoemulsification surgery, LPS, and arachidonic acid induced uveitis.
Physicochemical Properties
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M.Wt
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378.90
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Formula
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C20H27ClN2O3
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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O=C(O)CCC1=NN(CC2=CC(Cl)=CC=C2OCC(CC)CC)C(C)=C1
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References
1. David F Woodward, et al. ACS Pharmacol Transl Sci. 2020 Oct 26;3(6):1199-1210.
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