Chemical Structure : AGT-5
CAS No.:
1352173-01-3
AGT-5
(AGT5)
Catalog No.: PC-23187Not For Human Use, Lab Use Only.
AGT-5 is a indole-containing potential Aryl Hydrocarbon Receptor (AHR) fluorescent ligand, emits fluorescence in the near-infrared, shows AHR agonist activity.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AGT-5 is a indole-containing potential Aryl Hydrocarbon Receptor (AHR) fluorescent ligand, emits fluorescence in the near-infrared, shows AHR agonist activity.
AGT-5 demonstrated the ability to foster anti-inflammatory regulatory T cells (Treg) while suppressing pro-inflammatory T helper (Th)17 cells in vitro.
AGT-5 actively induced Treg differentiation from naïve CD4+ cells, and promoted Treg proliferation, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) expression and interleukin-10 (IL-10) production.
AGT-5 oral administration showed no toxicity when applied to zebrafish embryos. AGT-5 significantly upregulated Treg while downregulating pro-inflammatory Th1 cells in the mesenteric lymph nodes in C57BL/6 mice.
AGT-5 ameliorates type 1 diabetes in mice through regulatory cell activation in the early phase of the disease.
Physicochemical Properties
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M.Wt
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335.37
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Formula
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C22H13N3O
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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2-[2-[2-(1H-Indol-3-yl)ethenyl]-4H-1-benzopyran-4-ylidene]propanedinitrile
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References
1. Jonić N, et al. Molecules. (2024) 29:2988.
2. Jonić N, et al. Front Immunol. 2024 Sep 6;15:1454156.
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