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AH-23848 calcium salt

Chemical Structure : AH-23848 calcium salt

CAS No.: 81496-19-7

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AH-23848 calcium salt (AH23848, AH 23848)

Catalog No.: PC-70016Not For Human Use, Lab Use Only.

AH-23848 calcium salt is a dual antagonist of TP1 and EP4 receptors that inhibit TXA2-induced platelet aggregation with IC50 of 0.26 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AH-23848 calcium salt is a dual antagonist of TP1 and EP4 receptors that inhibit TXA2-induced platelet aggregation with IC50 of 0.26 uM.
    AH-23848 impairs PGE2-mediated relaxation of piglet saphenous vein by antagonizing the PGE2 receptor EP4.

    Physicochemical Properties

    M.Wt 496.6
    Formula C29H34NO5 • 1/2Ca
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (Z)-7-((1S,2S,5R)-5-([1,1'-biphenyl]-4-ylmethoxy)-3-oxo-2-(tetrahydro-2H-pyran-4-yl)cyclopentyl)hept-4-enoic acid

    References

    1. Brittain RT, et al. Circulation. 1985 Dec;72(6):1208-18.

    2. Coker SJ, et al. Br J Pharmacol. 1985 Sep;86(1):259-64.

    3. Qian X, et al. J Biol Chem. 2011 Jan 21;286(3):2111-20.

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