Chemical Structure : AHPC(Me)-C6-NH2
CAS No.:
2411422-49-4
AHPC(Me)-C6-NH2
((S,R,S)-AHPC(Me)-C6-NH2)
Catalog No.: PC-25389Not For Human Use, Lab Use Only.
AHPC(Me)-C6-NH2 is a potent, highly selective VHL-recruiting FBXO22 PROTAC degrader with DC50 of 77 nM in Jurkat cells, Dmax = 99%.
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Purity & Documentation Purity:
>98% (HPLC)
Biological Activity
AHPC(Me)-C6-NH2 is a potent, highly selective VHL-recruiting FBXO22 PROTAC degrader with DC50 of 77 nM in Jurkat cells, Dmax = 99%.
AHPC(Me)-C6-NH2 exhibits a highly selective degradation profile, with FBXO22 being the only protein efficiently degraded across the entire proteome.
AHPC(Me)-C6-NH2 (1-10 uM) induces robust FBXO22 degradation in THP-1 and HEK293T cells for 24 hours.
AHPC(Me)-C6-NH2 is effective for FBXO22 degradation by engaging C326.
AHPC(Me)-C6-NH2 mimics genetic loss of FBXO22 and serves as a chemical biology tool for probing its function.
Physicochemical Properties
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M.Wt
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571.78
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Formula
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C30H45N5O4S
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Appearance
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Solid
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CAS No.
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Storage
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- Solide Powder
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-20°C 12 Months; 4°C 6 Months
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- In Solvent
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-80°C 6 Months; -20°C 6 Months
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Shipping
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Solubility
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10 mM in DMSO
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Chemical Name/SMILES
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(2S,4R)-1-((S)-2-(7-aminoheptanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide
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References
1. Tian Qiu, et al. bioRxiv [Preprint]. 2025 Aug 20:2025.08.19.671158.
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