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AICP

Chemical Structure : AICP

CAS No.: 861213-66-3

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AICP (GluN2C agonist AICP)

Catalog No.: PC-60783Not For Human Use, Lab Use Only.

AICP is a potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AICP is a potent, selective GluN2C-selective NMDA receptor glycine site superagonist with EC50 of 1.7 nM at GluN1/2C.
    AICP is a full agonist at GluN1/2A (100% response compared with glycine), a partial agonist at GluN1/2B and GluN1/2D (10% and 27%, respectively), and a highly efficacious superagonist at GluN1/2C receptors (353%).
    AICP selectively enhances responses from recombinant GluN1/2C receptors in the presence of physiological glycine concentrations.

    Physicochemical Properties

    M.Wt 351.406
    Formula C20H21N3O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (R)-2-amino-3-(4-(2-ethylphenyl)-1H-indole-2-carboxamido)propanoic acid

    References

    1. Jessen M, et al. Mol Pharmacol. 2017 Aug;92(2):151-161.

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