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Chemical Structure : AIM-100
CAS No.: 873305-35-2
Catalog No.: PC-44307Not For Human Use, Lab Use Only.
AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $78 | In stock | |
| 10 mg | $118 | In stock | |
| 25 mg | $198 | In stock | |
| 50 mg | $298 | In stock | |
| 100 mg | Get quote |
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AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.
AIM-100 inhibits Ack1 Tyr284-phosphorylation attenuated pTyr267-AR transcriptional activity which in turn resulted in cell cycle arrest.
AIM-100 inhibits pTyr284 -Ack1 expression, and prostate cancer cell proliferation.
| M.Wt | 371.43 | |
| Formula | C23H21N3O2 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
|
| Chemical Name/SMILES |
Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]- |
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1. Mahajan K, et al. Prostate. 2010 Sep 1;70(12):1274-85.
2. Mahajan K, et al. Am J Pathol. 2012 Apr;180(4):1386-93.
3. Mahajan K, et al. J Biol Chem. 2012 Jun 22;287(26):22112-22.
4. DiMauro EF, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9.
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