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AIM-100

Chemical Structure : AIM-100

CAS No.: 873305-35-2

AIM-100 (AIM 100;AIM100)

Catalog No.: PC-44307Not For Human Use, Lab Use Only.

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

AIM-100 (AIM100) is a highly potent inhibitor of Ack1 (TNK2) (IC50=24 nM), selective for Ack1 over ABL1, BTK, Lck and LYN.
AIM-100 inhibits Ack1 Tyr284-phosphorylation attenuated pTyr267-AR transcriptional activity which in turn resulted in cell cycle arrest.
AIM-100 inhibits pTyr284 -Ack1 expression, and prostate cancer cell proliferation.

Physicochemical Properties

M.Wt 371.43
Formula C23H21N3O2
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO

Chemical Name/SMILES

Furo[2,3-d]pyrimidin-4-amine, 5,6-diphenyl-N-[[(2S)-tetrahydro-2-furanyl]methyl]-

References

1. Mahajan K, et al. Prostate. 2010 Sep 1;70(12):1274-85.

2. Mahajan K, et al. Am J Pathol. 2012 Apr;180(4):1386-93.

3. Mahajan K, et al. J Biol Chem. 2012 Jun 22;287(26):22112-22.

4. DiMauro EF, et al. Bioorg Med Chem Lett. 2007 Apr 15;17(8):2305-9.

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