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AJS1669

Chemical Structure : AJS1669

CAS No.: 1853130-05-8

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AJS1669 (AJS-1669, AJS 1669)

Catalog No.: PC-60250Not For Human Use, Lab Use Only.

AJS1669 (AJS-1669) is a novel potent, allosteric, orally available muscle glycogen synthase 1 (GYS1) activator with EC50 of 5.2 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AJS1669 (AJS-1669) is a novel potent, allosteric, orally available muscle glycogen synthase 1 (GYS1) activator with EC50 of 5.2 uM.
    AJS1669 shows no activity for GYS2.
    AJS1669 improves glucose metabolism and reduces body fat mass in mice.

    Physicochemical Properties

    M.Wt 512.504
    Formula C26H20F2NO6S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(5-(((4',5'-difluoro-2'-(methylthio)-[1,1'-biphenyl]-4-yl)oxy)methyl)furan-2-carbonyl)-N-(furan-2-ylmethyl)glycinate

    References

    1. Nakano K, et al. Int J Mol Med. 2017 Apr;39(4):841-850.

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