AKOS-22 (AKOS22, AKOS-022)

Chemical Structure : AKOS-22

CAS No.: 878983-38-1

Catalog No.: PC-25112Not For Human Use, Lab Use Only.

AKOS-22 (AKOS22, AKOS-022) is a poten, specific mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor with KD of 15.4 uM.

Packing	Price	Stock
5 mg	$88	In stock
10 mg	$128	In stock
25 mg	$218	In stock
50 mg	$358	In stock
100 mg		Get quote

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Biological Activity

AKOS-22 (AKOS22, AKOS-022) is a poten, specific mitochondrial protein VDAC1 (voltage-dependent anion channel 1) inhibitor with KD of 15.4 uM, interacts with VDAC1 and inhibits both VDAC1 oligomerization and apoptosis, protects against mitochondrial dysfunction.

Physicochemical Properties

M.Wt	467.87
Formula	C22H21ClF3N3O3
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(4-chlorophenyl)-3-(4-{[4-(trifluoromethoxy)phenyl]amino}piperidin-1-yl)pyrrolidine-2,5-dione

References

1. Ben-Hail D, et al. J Biol Chem. 2016 Nov 25;291(48):24986-25003.

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