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Chemical Structure : AKR1C3 PROTAC 5
Catalog No.: PC-22253Not For Human Use, Lab Use Only.
AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM.
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AKR1C3 PROTAC 5 is a first-in-class Aldo-Keto reductase 1C3 (AKR1C3) PROTAC degrader with DC50 of 52 nM in 22Rv1 cells, AKR1C1/C2 DC50 of 49 nM, ARv7 DC50 of 70 nM.
AKR1C3 PROTAC 5 is an effective degrader of AKR1C3, AKR1C1/2, and ARv7 in a concentration and proteasome dependent manner.
AKR1C3 PROTAC 5 reduces cell viability of in vitro prostate cancer models and potentiates enzalutamide through an AKR1C3-dependant effect.
| M.Wt | 841.88 | |
| Formula | C45H43N7O10 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Carmona AV, et al. Commun Chem. 2024 Apr 29;7(1):95.
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