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AKU-005

Chemical Structure : AKU-005

CAS No.: 1515855-85-2

AKU-005 (AKU005)

Catalog No.: PC-20488Not For Human Use, Lab Use Only.

AKU-005 is a potent, dual MAGL/FAAH inhibitor with IC50 of 589 and 309 pM for MAGL in rat and mouse brain membrane respectively, inhibits rat and human FAAH with IC50 of 63 and 389 nM.

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    Biological Activity

    AKU-005 is a potent, dual MAGL/FAAH inhibitor with IC50 of 589 and 309 pM for MAGL in rat and mouse brain membrane respectively, inhibits rat and human FAAH with IC50 of 63 and 389 nM.

    Physicochemical Properties

    M.Wt 347.42
    Formula C20H21N5O
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO

    Chemical Name/SMILES

    (4-benzhydrylpiperazin-1-yl)(1H-1,2,4-triazol-1-yl)methanone

    References

    1. Niina Aaltonen, et al. Chem Biol. 2013 Mar 21;20(3):379-90.

    2. Adriana Della Pietra, et al. J Headache Pain. 2023 Apr 11;24(1):38.

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