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AL-9

Chemical Structure : AL-9

CAS No.: 869218-90-6

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AL-9 (HCV inhibitor AL-9)

Catalog No.: PC-63342Not For Human Use, Lab Use Only.

AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AL-9 is a small molecule HCV replication inhibitor with EC50 of 0.29 and 0.75 uM for genotype 1b and 2a, inhibits purified PI4KIIIα with IC50 of 0.57 uM.
    AL-9 inhibits HCV across different genotypes with activity in the sub-micromolar to low micromolar range in the absence of significant cytotoxic effects.
    AL-9 inhibits PI4KIIIα also in living cells, while not appreciably affecting the activity of PI4KIIIβ, does not affect the level of PI4P in the Golgi membrane.

    Physicochemical Properties

    M.Wt 402.454
    Formula C23H22N4O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20 °C 12 Months; 4°C 6 Months
    In Solvent
    -80 °C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (5-(4-((4-morpholinophenyl)amino)quinazolin-6-yl)furan-2-yl)methanol

    References

    1. Bianco A, et al. PLoS Pathog. 2012;8(3):e1002576.

    2. MacLeod AM, et al. ACS Med Chem Lett. 2013 May 8;4(7):585-9.

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