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AL906

Chemical Structure : AL906

CAS No.: 2568001-41-0

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AL906 (AL 906, AL-906)

Catalog No.: PC-72058Not For Human Use, Lab Use Only.

AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation).

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    AL906 (AL 906) is a novel potent, selective EGFR inhibitor with IC50 of 12 nM (EGFR phosphorylation).
    AL906 blocked EGF-induced EGFR phosphorylation at doses as low as 1 uM in EGF-stimulated OV90 and DU145 cells.
    AL906 growth inhibitory activity was superior to that of the clinical drug gefitinib.
    AL906 selectively inhibited the growth of the NIH3T3-EGFR and HER2 transfectants in isogenic NIH3T3 transfected cell panel.

    Physicochemical Properties

    M.Wt 695.137
    Formula C34H31ClN10O5
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Month
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-(4-((3-chlorophenyl)amino)quinazolin-6-yl)-4-((methyl(2-(3-((7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino)propanamido)ethyl)amino)methyl)benzamide

    References

    1. Nahid Golabi, et al. Invest New Drugs. 2021 Feb;39(1):240-250.

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