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Chemical Structure : ALE-0540
Catalog No.: PC-61913Not For Human Use, Lab Use Only.
ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.
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ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively; produces antiallodynic actions in models of neuropathic pain.
Pain
Discontinued
| M.Wt | 301.258 | |
| Formula | C14H11N3O5 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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1. Owolabi JB, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6.
2. Eibl JK, et al. Eur J Pharmacol. 2013 May 15;708(1-3):30-7.
3. Sheffield KS, et al. Pharmacol Res. 2016 Jan;103:292-9.
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