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ALE-0540

Chemical Structure : ALE-0540

CAS No.: 234779-34-1

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ALE-0540 (ALE0540)

Catalog No.: PC-61913Not For Human Use, Lab Use Only.

ALE-0540 is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.

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5 mg $138 In stock
10 mg $218 In stock
25 mg $368 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALE-0540 (ALE0540) is a nerve growth factor (NGF) antagonist that inhibits the binding of NGF to TrkA or both p75 and TrkA with IC50 of 5.88 and 3.72 uM, respectively.
ALE-0540 produces antiallodynic actions in models of neuropathic pain.

Physicochemical Properties

M.Wt 301.258
Formula C14H11N3O5
Appearance Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(2-Hydroxyethylamino)-5-nitrobenzo[de]isoquinoline-1,3-dione

References

1. Owolabi JB, et al. J Pharmacol Exp Ther. 1999 Jun;289(3):1271-6.

2. Eibl JK, et al. Eur J Pharmacol. 2013 May 15;708(1-3):30-7.

3. Sheffield KS, et al. Pharmacol Res. 2016 Jan;103:292-9.

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