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ALESIA

Chemical Structure : ALESIA

CAS No.: 2035006-55-2

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ALESIA (S1PR3 agonist)

Catalog No.: PC-72841Not For Human Use, Lab Use Only.

ALESIA is a sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALESIA is a specific sphingosine-1-phosphate receptor 3 (S1PR3)-G12-biased agonist and selectively induces G12 signal.
    ALESIA promotes nitric oxide production and oxidative stress.
    ALESIA selectively induces apoptosis in cancer cells because of low glucose levels.
    Intraperitoneal administration of ALESIA improved the survival of mice with peritoneally disseminated rhabdomyosarcoma.
    ALESIA (Anticancer Ligand Enhancing Starvation-induced Apoptosis) is a new anticancer compound for glucose starvation therapy.

    Physicochemical Properties

    M.Wt 456.5
    Formula C22H24F4N2O2S
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    4-fluoro-N-(2-((4aS,8aR)-octahydroisoquinolin-2(1H)-yl)-5-(trifluoromethyl)phenyl)benzenesulfonamide

    References

    1. Masayasu Toyomoto, et al. Cell Chem Biol. 2021 Aug 19;28(8):1132-1144.e9.

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