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ALG-055009

Chemical Structure : ALG-055009

CAS No.: 2542029-03-6

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ALG-055009 (ALG055009)

Catalog No.: PC-22997Not For Human Use, Lab Use Only.

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.

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10 mg $118 In stock
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Purity & Documentation Purity: >98% (HPLC) Select Batch:

Biological Activity

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.
ALG-055009 (>0.075 mg/kg) reduces serum lipid levels in a high fat diet rat model, significantly increases hepatic Dio1 and Me1 gene expression at doses of 0.15 and 0.5 mg/kg.

Physicochemical Properties

M.Wt 425.23
Formula C16H14Cl2N6O4
Appearance Solid
CAS No.
Storage
Solide Powder
-20°C 12 Months; 4°C 6 Months
In Solvent
-80°C 6 Months; -20°C 6 Months
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

6-Amino-2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)oxy]phenyl]-4H-1,2,4-triazine-3,5-dione

References

1. Vandyck K, et al. J Med Chem. 2024 Sep 2. doi: 10.1021/acs.jmedchem.4c01029.

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