ALG-055009 | THRβ agonist | Probechem Biochemicals

Chemical Structure : ALG-055009

ALG-055009 (ALG055009)

Catalog No.: PC-22997Not For Human Use, Lab Use Only.

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.

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Biological Activity

ALG-055009 is a potent, selective thyroid hormone receptor β (THR-β) agonist with EC50 of 63 nM, 5.7 fold selective over THR-α.
ALG-055009 (>0.075 mg/kg) reduces serum lipid levels in a high fat diet rat model, significantly increases hepatic Dio1 and Me1 gene expression at doses of 0.15 and 0.5 mg/kg.

Physicochemical Properties

M.Wt	425.23
Formula	C16H14Cl2N6O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20°C 12 Months; 4°C 6 Months	In Solvent -80°C 6 Months; -20°C 6 Months
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-Amino-2-[3,5-dichloro-4-[(5-isopropyl-6-oxo-1H-pyridazin-3-yl)oxy]phenyl]-4H-1,2,4-triazine-3,5-dione

References

1. Vandyck K, et al. J Med Chem. 2024 Sep 2. doi: 10.1021/acs.jmedchem.4c01029.

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ALG-055009 (ALG055009)

Biological Activity

Physicochemical Properties

References

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