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ALK2 R206H inhibitor 23

Chemical Structure : ALK2 R206H inhibitor 23

CAS No.: 3046314-77-3

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ALK2 R206H inhibitor 23

Catalog No.: PC-72134Not For Human Use, Lab Use Only.

ALK2 R206H inhibitor 23 is a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2/ACVR1) with IC50 of 8 nM for mutant ALK2 R206H.

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Purity & Documentation Purity: >98% (HPLC) Select Batch:

    Biological Activity

    ALK2 R206H inhibitor 23 is a potent and selective inhibitor of Activin Receptor-Like Kinase-2 (ALK2/ACVR1) with IC50 of 8 nM for mutant ALK2 R206H.
    ALK2 R206H inhibitor 23 displays >15-fold selectivity over ALK1/ALK3, and >100-fold over ALK5/ALK6.

    Physicochemical Properties

    M.Wt 555.12
    Formula C29H39ClN6O3
    Appearance Solid
    CAS No.
    Storage
    Solide Powder
    -20°C 12 Months; 4°C 6 Months
    In Solvent
    -80°C 6 Months; -20°C 6 Months
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-amino-6-(2-chloro-4-((4-morpholinopiperidin-1-yl)methyl)phenyl)-N-(4-hydroxybicyclo[2.2.2]octan-1-yl)pyrazine-2-carboxamide

    References

    1. Thomas Ullrich, et al. Bioorg Med Chem Lett. 2022 May 15:64:128667.

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