ALLM (Ac-Leu-Leu-Met-CHO) is a potent, cell-permeable calpain inhibitor with Ki of 0.6 and 100 nM for calpain L and calpain B, respectively.
ALLM inhibits the activities of Ca(2+)-dependent neutral proteases as well as lysosomal proteases, including cathepsin L, cathepsin B, and cathepsin D.
ALLM induces apoptosis in rat pituitary tumor cells by specific caspase activation.
Physicochemical Properties
M.Wt
401.57
Formula
C19H35N3O4S
Appearance
Solid
CAS No.
Storage
Solide Powder
-20 °C 12 Months; 4°C 6 Months
In Solvent
-80 °C 6 Months; -20°C 6 Months
Shipping
Solubility
10 mM in DMSO
Chemical Name/SMILES
N-Acetyl-L-leucyl-L-leucyl-L-methional
References
1. Neumann D, et al. Biochem J. 1996 Jan 15;313 ( Pt 2):391-9.
