ALS-8112 |CAS:1445379-92-9 Probechem Biochemicals

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Chemical Structure : ALS-8112

ALS-8112 (ALS 8112;ALS8112)

Catalog No.: PC-43306Not For Human Use, Lab Use Only.

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Purity & Documentation Purity: >98% (HPLC)

Biological Activity

ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase (IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.
ALS-8112 is the active form of ALS-8176, inhibits all strains of RSV in vitro and is specific for paramyxoviruses and rhabdoviruses.

Physicochemical Properties

M.Wt	293.6793
Formula	C10H13ClFN3O4
Appearance	Solid
CAS No.
Storage	Solide Powder -20 °C 12 Months; 4°C 6 Months	In Solvent -80 °C 6 Months; -20°C 6 Months
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Solubility	DMSO: ≥ 47 mg/mL
Chemical Name/SMILES	Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-

References

1. Deval J, et al. PLoS Pathog. 2015 Jun 22;11(6):e1004995.

2. Wang G, et al. J Med Chem. 2015 Feb 26;58(4):1862-78.

3. Jordan PC, et al. ACS Chem Biol. 2017 Jan 20;12(1):83-91.

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ALS-8112 (ALS 8112;ALS8112)

Biological Activity

Physicochemical Properties

References

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