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Chemical Structure : ALS-8112
Catalog No.: PC-43306Not For Human Use, Lab Use Only.
ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase (IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.
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ALS-8112 is a potent, selective RSV polymerase inhibitor, the 5'-triphosphate of ALS-8112 (ALS-8112-TP) inhibits RSV polymerase (IC50=20 nM) without appreciable inhibition of human DNA and RNA polymerases.
ALS-8112 is the active form of ALS-8176, inhibits all strains of RSV in vitro and is specific for paramyxoviruses and rhabdoviruses.
| M.Wt | 293.6793 | |
| Formula | C10H13ClFN3O4 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
DMSO: ≥ 47 mg/mL |
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1. Deval J, et al. PLoS Pathog. 2015 Jun 22;11(6):e1004995.
2. Wang G, et al. J Med Chem. 2015 Feb 26;58(4):1862-78.
3. Jordan PC, et al. ACS Chem Biol. 2017 Jan 20;12(1):83-91.
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