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Chemical Structure : ALS-8176
CAS No.: 1445385-02-3
Catalog No.: PC-43307Not For Human Use, Lab Use Only.
ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM.
| Packing | Price | Stock | Quantity |
|---|---|---|---|
| 5 mg | $325 | In stock | |
| 25 mg | $695 | In stock | |
| 100 mg | $1580 | In stock | |
| 250 mg | Get quote |
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ALS-8176 (Lumicitabine) is the 3',5'-di-O-isobutyryl prodrug of ALS-8112 5'-triphosphate (ALS-8112-TP), which is a potent, selective RSV polymerase inhibitor with IC50 of 20 nM; demonstrates good oral bioavailability and a high level of ALS-8112-TP in vivo, exhibits excellent anti-RSV efficacy and safety in vivo and clinical trials.
RSV Infection
Phase 2 Clinical
| M.Wt | 433.859 | |
| Formula | C18H25ClFN3O6 | |
| Appearance | Solid | |
| Storage |
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| Solubility |
10 mM in DMSO |
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| Chemical Name/SMILES |
Cytidine, 4'-C-(chloromethyl)-2'-deoxy-2'-fluoro-, 3',5'-bis(2-methylpropanoate) |
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1. Deval J, et al. PLoS Pathog. 2015 Jun 22;11(6):e1004995.
2. Wang G, et al. J Med Chem. 2015 Feb 26;58(4):1862-78.
3. Jordan PC, et al. ACS Chem Biol. 2017 Jan 20;12(1):83-91.
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